2024-03-28T22:44:31Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00017967
2022-12-15T03:49:16Z
453:456
471:537:538:1127
The Sort and Portion of Malignant Transformation in Gastric Adenoma : By p53 and Ki-67 Immunostaing
胃腺腫の癌化率と癌の形態発生 : p53とKi-67免疫染色からみて
胃腺腫の癌化率と癌の形態発生 : p53とKi-67免疫染色からみて
前島, 威人
112785
gastric adenoma
p53 immunostaining
Ki-67 immunostaining
cancer in adenoma
胃腺腫
p53 免疫染色
Ki-67 免疫染色
腺腫内癌
The aim of this study was to elucidate what sort of gastric adenoma transforms into malignancy and where cancer develops in adenomatous tubule. The object was 111 gastric adenomas and 10 carcinoma arising in adenoma. p53 and Ki-67 immunostaing was performed for objective detection of small foci of microscopic carcinoma. Malignant transformation was found only in adenoma of high-grade cytological atypia and of 19mm or more in size. The rate was 8.3% (10/121) in total, 0% (0/71) in tumors less than 10mm, 8.7% (2/23) in 10≦x<20mm tumors, and 29.2% (8/27) in 20≦x tumors. Microscopic cancer was found in the proliferative zone (superficial layer) of adenomatous tubules by p53 immunostaing. The cancer tissue was of low-grade in cytological atypia, and cancer cells were Ki-67 positive. Then, cancer cells extended downwards along the adenomatous tubules. This is the first report which objectively verified these processes by p53 and Ki-67 immunostaing.
departmental bulletin paper
新潟医学会
1996-08
application/pdf
新潟医学会雑誌
8
110
337
347
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/17967/files/110(8)_337-347.pdf
jpn