2024-03-29T10:21:41Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00017717
2022-12-15T03:48:55Z
453:456
471:537:538:1122
Analysis of Tumor Suppressor Gene Alterations in Human Glioma Cell Lines
グリオーマ細胞株におけるがん抑制遺伝子変化の解析
グリオーマ細胞株におけるがん抑制遺伝子変化の解析
張, 淑靖
111501
熊西, 敏郎
111502
Glioma
Brain tumor
Tumor suppressor gene
p16 gene
p15 gene
p53 gene
p21 gene
グリオーマ
脳腫瘍
がん抑制遺伝子
p16 遺伝子
p15 遺伝子
p53 遺伝子
p21 遺伝子
Ten glioma cell lines were examined for alterations of the p16, p15 and p53 genes, which were tumor suppressor genes with direct or indirect CDK inhibitory functions. All the cell lines showed abnormalities in at least 1 gene, often in 2 or 3 genes coincidentally, suggesting that dysfunction of these genes is closely related to glioma cell growth. On examination of the primary tumor tissues, the same alterations of the p16/p15 and p53 genes as detected in the cell lines were demonstrated in all 6 cases examined, p16/p15 gene deletion in 1, p16 gene mutation in 1 and p53 gene mutations in 5 cases. This suggested that the p16/p15 and p53 gene alterations and their combinations in at least some glioma cell lines reflected those in the primary glioma tissues.
departmental bulletin paper
新潟医学会
1997-01
application/pdf
新潟医学会雑誌
1
111
47
56
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/17717/files/111(1)_47-56.pdf
jpn