2024-03-29T13:21:02Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00017419
2022-12-15T03:48:44Z
453:456
471:537:538:545
Clinicopathological Study of 41 Resected Small Cell Lung Carcinomas
肺小細胞癌切除症例の免疫組織学的検討
肺小細胞癌切除症例の免疫組織学的検討
中山, 健司
109950
江口, 昭治
109951
clinicopathological study
small cell lung carcinoma
chromogranin A
prognostic factor
免疫組織学的検討
肺小細胞癌
クロモグラニンA
予後因子
Using histopathological method, we analyzed the relationships among the subtypes, localization of the tumors, chemotherapeutic effects, and prognosis of the diseases in 41 small cell lung carcinoma patients surgically resected in our department and Nishi-Niigata Hp.Keratin,epithelial membrane antigen(EMA)and carcinoembryonic antigen(CEA)were used as markers of epithelial cells, gastrin releasing peptide(GRP), chromogranin A(chr. A), neuronspecific enolase(NSE)and Leu 7 were used as markers of neuroendocrine cells, and c-myc, p53 were used. Patients were classified into 3 subtypes:1)oat cell carcinoma(OAT), 2)intermediate cell type(INT), and 3)small cell carcinoma with large cell component(SC/LC)according to the Radice's criteria. Immunohistological positive rate are as follows. Keratin 60%, EMA 84%, CEA 74%, GRP 62%, chr. A 47%, NSE 97%, Leu 7 62%, p53 32%, c-myc 49%. There were no differences in parcentages of positive staining among the subtypes and the localization of the tumors. The cases of positive staining for GRP and the cases of negative staining for kertin were reactive for chemotherapy. The mean 5-year survival was greater in patients with nagative staining for chr. A than in patients with positive staining for chr. A. chr. A might be a prognostic factor for SCLC.
departmental bulletin paper
新潟医学会
1997-05
application/pdf
新潟医学会雑誌
5
111
311
318
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/17419/files/111(5)_311-318.pdf
jpn