2024-03-28T17:49:27Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00017289
2022-12-15T03:48:40Z
453:456
471:537:538:1118
Influence of L-Nitroarginine on Nicorandil- and Cromakalim-Induced Increases in Coronary Flow in Isolated Guinea Pig Heart
モルモット灌流心におけるnicorandilおよびcromakalimの冠流量増加作用におよぼすL-nitroarginineの影響について
モルモット灌流心におけるnicorandilおよびcromakalimの冠流量増加作用におよぼすL-nitroarginineの影響について
神, 裕雅
109180
K^+ channel opener
EDRF
L-nitroarginine
coronary vasodilation
isolated guinea pig heart
K^+ チャネル開口薬
内皮由来拡張因子
L-ニトロアルギニン
冠血管拡張
モルモット摘出心
Possible contribution of endothelium-derived relaxing factor (EDRF) to nicorandil- and cromakalim-induced coronary vasodilations was studied in isolated guinea pig hearts. Increases in coronary flow induced by nicorandil, cromakalim and adenosine were significantly inhibited by pretreatment with glibenclamide, an antagonist of ATP sensitive K^+ channel, while those by acetylcholine and papaverine were not. Pretreatment with L-nitroarginine(L-NA), an inhibitor of constitutive nitric oxide synthetase, or with methylene blue (MB), an inhibitor of guanylate cyclase, resulted in a significant inhibition of nicorandil-, cromakalim-, acetylcholine- and adenosine-induced increases in coronary flow. Papaverine-induced increase was not affected by pretreatment with L-NA or MB. These results suggest that the release of EDRF from vascular endothelium is responsible in part for coronary vasodilation induced by nicorandil and cromakalim.
departmental bulletin paper
新潟医学会
1997-07
application/pdf
新潟医学会雑誌
7
111
452
459
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/17289/files/111(7)_452-459.pdf
jpn