2024-03-29T13:52:34Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00017078
2022-12-15T03:48:31Z
453:456
471:537:538:1116
Pathogenesis of Lupus Nephritis : Role of Histones, DNA, Nucleosome, Anti-Nuclear Antibodies
ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割
ループス腎炎発症機序 : ヒストン・DNA・ヌクレオソーム・抗核抗体の役割
森岡, 哲夫
108074
lupus nephritis
nucleosome
charge
histones
anti-DNA antibody
ループス腎炎
ヌクレオソーム
荷電
ヒストン
抗 DNA 抗体
A possibility involving cationic nuclear autoantigens is presented in detail. Histone was employed as a model antigen, representative of this group. Histones were shown to have high affinity for the rat GBM;they could also acted as planted antigen and induce IC formation;furthermore they were able to mediate the binding of highly anionic DNA. The demonstration of histones in glomerular deposits in both lupus mice and patients with SLE is important evidence, linking such molecules with the kidney lesions. Nucleosome-like structures as well as nucleosome-anti-DNA immune complexes were shown to have the affinity for the GBM. We discussed the importance of the nucleosome in the induction of lupus nephritis.
departmental bulletin paper
新潟医学会
1997-09
application/pdf
新潟医学会雑誌
9
111
541
546
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/17078/files/111(9)_541-546.pdf
jpn