2024-03-28T15:09:11Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00017040
2022-12-15T03:48:27Z
453:456
471:537:538:1115
Hematological Abnormalities Caused by Smoking : the Association with Myelodysplastic Syndrome
喫煙による血液異常 : 骨髄異形成症候群との関連について
喫煙による血液異常 : 骨髄異形成症候群との関連について
高橋, 益広
107804
寺尾, 亜陽佳
107805
村田, 真理
107806
重野, 直也
107807
高橋, 英伸
107808
黒羽, 高志
107809
増子, 正義
107810
鈴木, 訓充
107811
古川, 達雄
107812
成田, 美和子
107813
小池, 正
107814
相澤, 義房
107815
smoking
leukocytosis
macrocytosis
myelodysplastic syndrome
喫煙
白血球増加症
大赤血球症
骨髄異形成症候群
The analysis on the association of smoking with hematological findings demonstrated remarkable increases of leukocyte counts, mean corpuscular hemoglobin, and mean corpuscular volume in smokers. Although it is believed that smoker's polycythemia is caused by oxygendeficiency induced hypererythropoietinemia, an increase of erythrocyte counts was not demonstrated in the present study. Thinking our data together with the previous reports concerning the impairment of erythrocyte functions such as deformability in smokers, the appearance of macrocytosis was considered to be due to intrinsic abnormality of erythrocytes in smokers. The previous reports concerning abnormal leukocyte function in smokers elicited the idea that increased leukocytes may be also involved in intrinsic abnormality. The abnormalities spreading to both erythrocytes and leukocytes in some of smokers were thought to be derived from pluripotent stem cells. Recent reports concerning high incidence of myelodysplastic syndrome in smokers and macrocytosis as the initial sign of myelodysplastic syndrome, together with our data of macrocytosis in smokers, suggest the progression of some smokers with macrocytosis to myelodysplastic syndrome.
departmental bulletin paper
新潟医学会
1997-10
application/pdf
新潟医学会雑誌
10
111
647
655
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/17040/files/111(10)_647-655.pdf
jpn