2024-03-29T10:27:40Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00016795
2022-12-15T03:48:17Z
453:456
471:537:538:1109
Regulation of Voltage-Gated K^+ Channel mRNA Expression by Thyroid Hormone in Rat Ventricle
甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御
甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御
阿部, 晃
106532
potassium channel
thyroid hormone
T3 receptor
カリウムイオンチャネル
甲状腺ホルモン
T3受容体
Since effects of thyroid hormones on cardiac function or rhythm has been shown, wheater triiodethyronine (T3) modulates voltage-gated potassium channel gene expression in rat heart or not was studied in the present study. The mRNA expression of five K^+ channel subunits (kv 1.2, kv 1.4, kv 1.5, kv 2.1 and kv 4.2) in rat ventricle was examined by RNase protection assay in rat which were treated with T3 or propylthyouracil (PTU) and was compared with control rats. Kv 1.2 mRNA expression strongly decreased in the ventricles of T3-treated rats, whereas Kv 1.5 mRNA increased, comparing to control rat ventricles. In contrast, Kv 1.5 mRNA expression in the ventricles strongly decreased and Kv 1.2 mRNA expression increased in PTU-treated rats. Interestingly, Kv 1.4 mRNA expression in ventricle was obviously enhanced by PTU-treatment although it was hardly detectable in control or T3-treated rat ventricles. The down-regulation of the ventricular Kv 1.5 mRNA expression by PTU was restored by administration of T3. No changes of Kv 2.1 and Kv 4.2 mRNA expression in ventricles were observed by the T3 or PTU treatment. These findings suggest that thyroid hormone influences mRNA expression of Shaker-related potassium channel genes (Kv 1.2, Kv 1.4 and Kv 1.5) in rat heart through T3 receptormediated regulation at a transcriptional level by an individually different direction.
departmental bulletin paper
新潟医学会
1998-04
application/pdf
新潟医学会雑誌
4
112
199
208
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/16795/files/112(4)_199-208.pdf
jpn