2024-03-29T09:27:42Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00015723
2022-12-15T03:47:24Z
453:456
471:537:538:543
Interindividual Differences in Metabolism of Psychotropic Drugs and Drug-Drug Interaction
向精神薬代謝の個体差と薬物相互作用:薬理遺伝学の進歩とその応用について
向精神薬代謝の個体差と薬物相互作用:薬理遺伝学の進歩とその応用について
染矢, 俊幸
176642
metabolism of psychotropic drugs
drug-drug interaction
plasma concentration
genetic polymorphism
cytochrome P450
向精神薬代謝
薬物相互作用
血中濃度
遺伝的多型
チトクロームP450
The development of pharmacokinetics and pharmacogenetics in a last decade has been clarifying the background of remarkable interindividual variability in the metabolism of psychotropic drugs and its clinical significance. This article reviewed the followings: Interindividual variability in plasma concentration of psychotropic drugs, relationship between plasma concentration of psychotropic drugs and its clinical effect, genetic polymorphism of the enzyme which is involved in psychotropic drug metabolism, pharmacokinetic drug-drug interaction, effect of aging on pharmacokinetics, etc.. On the basis of further development of this area in psychiatry, it is desired that more rational psychiatric pharmacotherapy will be established.
departmental bulletin paper
新潟医学会
1999-12
application/pdf
新潟医学会雑誌
11-12
113
507
515
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/15723/files/113(11-12)_507-515.pdf
jpn