2024-03-29T05:45:33Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00015602
2022-12-15T03:47:14Z
453:456
471:537:538:1090
Chemotherapy
1) 化学療法(シンポジウム 進行癌の治療, 第548回新潟医学会)
1) 化学療法(シンポジウム 進行癌の治療, 第548回新潟医学会)
張, 高明
99908
Advanced cancer
Chemotherapy
Combination modality treatment
New therapeutic approach
進行癌
化学療法
集学的治療
新規治療戦略
Chemotherapy has been playing a major role in the treatment of various cancers especially in advanced stage. Chemotherapy is the only way to get complete disappearance of tumor cells (total cell kill) in hematological malignancies, such as acute leukemia and lymphoma. Several therapeutic strategies including highdose chemotherapy with stem cell transplantation has been performed and resulted in the cure of the diseases, even in case of advanced, refractory phase. These results demonstrated that complete remission or response is essential for the ultimate cure of the disease, since there is no cure in case of partial response or stable disease. Unfortunately, present chemotherapeutic approaches are not effective enough to get CR in various solid tumors. The main reason for this tragety is that the chemotherapeutic agents used in current treatment protocol do not possess enough anti-tumor activity to eradicate vast majority of the tumor cells. Palliative chemotherapy should also be considered in case of advanced cancer with minimal chemo-sensitivity. Because of this, development of new cytotoxic anticancer agents is essential. Other than this, different therapeutic approaches, such as clinical application of apoptosis inducing agents, angiogenesis inhibitor, and adhesion molecule blocker, which may inhibit distant metastases.
departmental bulletin paper
新潟医学会
2000-02
application/pdf
新潟医学会雑誌
2
114
35
38
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/15602/files/114(2)_35-38.pdf
jpn