2024-03-28T10:39:56Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00014894
2022-12-15T03:46:47Z
453:456
471:537:538:1075
Polygenic Approaches to Sporadic Alzheimer Disease
孤発性アルツハイマー病への多因子遺伝学的アプローチ
孤発性アルツハイマー病への多因子遺伝学的アプローチ
奥泉, 薫
95984
sporadic Alzheimer disease
polygenic disease
apolipoptotein E gene
very low density lipoprotein receptor gene
孤発性アルツハイマー病
多因子遺伝病
アポリポ蛋白E遺伝子
VLDL受容体遺伝子
Alzheimer disease (AD) is the most common cause of dementia. Accumulation of senile plaques and neurofibrillary tangles is the characteristic neuropathological manifestation of the disease. Recent investigations have revealed the presence of apolipoprotein E (apoE) in these structures. APOE 4 is one of the genotypes of apoE isoforms. First, the results of this study revealed that APOE 4 is a susceptibility gene for sporadic AD in Japanese, especially with early age of onset. Second, this study focused on the gene for the very low density lipoprotein (VLDL) receptor which is one of the receptors for apoE. Association studies were performed using a polymorphic triplet repeat in the gene for the VLDL receptor. The results indicated the possibility that the VLDL receptor gene is associated with sporadic AD in Japanese, but the association was not significant in the Caucasian population.
departmental bulletin paper
新潟医学会
2001-05
application/pdf
新潟医学会雑誌
5
115
176
182
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/14894/files/115(5)_176-182.pdf
jpn