2024-03-28T18:15:51Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00014800
2022-12-15T03:46:43Z
453:456
471:537:538:1073
Searching for Genes involved in Pathological Processes of Chronic Glomerulonephritis
慢性糸球体腎炎の病態関連遺伝子の探求
慢性糸球体腎炎の病態関連遺伝子の探求
山本, 格
95423
chronic glomerulonephritis
gene expression
gene search
慢性糸球体腎炎
遺伝子発現
遺伝子探索
No efficient therapeutic methods or drugs have been developed for human chronic glomerulonephritis probably because the pathogens and the pathological mechanisms were not well understood. Although several candidates were proposed as possible pathogens of the disease, none of them have been confirmed to be pathogenic yet. Experimental glomerulonephritis models have been extensively studied to understand the pathological processes of the models and also human chronic glomerulonephritis. Examined chiefly was whether mechanisms shown to play crucial roles in inflammatory processes of other tissues or organs were involved or not in the experimental glomerulonephritis models. However, mechanisms or molecules involved specifically in chronic glomerulonephritis have not been elucidated by these trials. To understand the pathological processes as molecular interactions, all molecules present in the diseased glomeruli need to be clarified whether they may be already known or not. To make this possible we aimed to search for genes uniquely expressed in normal and diseased glomeruli and to interpret the pathological processes as molecular interactions and integration of gene products.
departmental bulletin paper
新潟医学会
2001-07
application/pdf
新潟医学会雑誌
7
115
287
292
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/14800/files/115(7)_287-292.pdf
jpn