2024-03-28T10:22:42Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00014063
2022-12-15T03:46:17Z
453:456
471:537:538:1058
Spinal Cord Injury by Transient Ischemia is Reduced in Mice Deficient in the ε 1 (NR2A) Subunit of NMDA Receptor Channel
NMDA型グルタミン酸受容体 ε 1サブユニットは虚血性脊髄神経細胞死機構の主要な因子である
NMDA型グルタミン酸受容体 ε 1サブユニットは虚血性脊髄神経細胞死機構の主要な因子である
島田, 晃治
91651
NMDA receptor channel glutamate
ε 1 subunit neurotoxicity
spinal cord ischemia
The role of glutamate neurotoxicity in spinal cord has been advocated but still remains controversial. In spinal cord, as well as other central nervous system tissues, glutamate receptors are thought to participate in neuronal cell death by transient ischemia, but it is not clear which subtype of glutamate receptor cannels acts in the mechanism of excitotoxicity. To elucidate the involvement of glutamate receptors, especially NMDA receptors, in spinal cord ischemic injury, we used mutant mice deficient in the ε 1 (NR 2 A) subunit of NMDA receptor. The mutant mice were subjected to transient spinal cord ischemia by clamping aortic arch and left subclavian artery and examined for 48 hours after ischemia. Their motor dysfunction and histopathological damage were significantly milder compared with wild type mice. These results indicate that NMDA receptors which contain ε 1 subunit play important role in the mechanism of neurotoxicity in spinal cord.
departmental bulletin paper
新潟医学会
2002-10
application/pdf
新潟医学会雑誌
10
116
472
481
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/14063/files/KJ00000142128.pdf
jpn