2024-03-28T10:16:48Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00008797
2022-12-15T03:43:04Z
453:456
471:537:538:917
Clinical Application of Cultured Human Periosteum Sheet for Periodontitis Patients
2 培養骨膜シート移植による歯周病治療(シンポジウム 再生医療による難治性疾患治療の幕開け, 第693回新潟医学会)
2 培養骨膜シート移植による歯周病治療(シンポジウム 再生医療による難治性疾患治療の幕開け, 第693回新潟医学会)
奥田, 一博
61244
川瀬, 知之
61245
中田, 光
61246
吉江, 弘正
61247
佐伯, 万騎男
61248
chronic periodontitis
clinical attachment level
cultured periosteal sheet
radiographic infrabony defect depth
5-year results
long-term safety
To regenerate periodontal tissue destroyed by chronic periodontitis, autologous cultured periosteal sheets in combination with platelet-rich plasma (PRP) and hydroxyapatite (HA) granules were used as a clinical application. The periosteum specimens were dissected from each patient, and were incubated for approximately six weeks until the sheets were formed. Prior to placement of the cultured periosteal sheets, osseous defects were thoroughly debrided and filled with HA granules in combination with PRP. Standardized clinical and radiographic measurements were determined during follow-up examinations at one, two, three, four and five years. Clinical attachment level (CAL) and radiographic infrabony defect depth (IBD) were determined as primary end-point. One year results of this treatment have shown favorable clinical results, and these effects were stable and maintained after five years, when compared to baseline and three years. The cultured periosteal sheets function as a living drug delivery system to favorably influence cellular functions and serves as seeds for ectopic bone formation near the implantation site through production of important growth factors related to periodontal regeneration. Tissue engineering is a novel means which we believe will be used extensively in the future to treat periodontal osseous defects. Once a successful clinical treatment has been achieved with a combination of HCP sheets, PRP and HA granules, the results are maintainable 5 years. In addition to the favorable long term clinical results for treating periodontal osseous defects, the long-term safety of tissue engineered HCP sheets in periodontal therapy was established.
departmental bulletin paper
新潟医学会
2014-11
application/pdf
新潟医学会雑誌
11
128
568
573
新潟医学会雑誌
AN00182415
00290440
https://niigata-u.repo.nii.ac.jp/record/8797/files/128(11)_568-573.pdf
jpn