2024-03-29T14:59:49Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006686
2022-12-15T03:40:00Z
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471:537:568:658
Expiration of radioactive carbon dioxide by rats after administration of isotopic lactate and acetate
Expiration of radioactive carbon dioxide by rats after administration of isotopic lactate and acetate
Kuze, Shougo
53938
Ito, Yusuke
53939
Miyahara, Tatsuro
53940
To clarify the oxidation of lactate and acetate contained in lactated and acetated Ringer's solutions, carbon dioxide productions from these compounds were investigated following a single intravenous injection of 1 mmol • kg^<-1> of [1-^<14>C] labelled DL-sodium lactate, L-sodium lactate or sodium acetate in unanesthetized rats. For DL-lactate, cumulative expired ^<14>CO_2 rates of total radioactivities of administered ^<14>C were, respectively, 16%, 37%, 63%, 70%, and 72%, at 15 minutes, 30 minutes, one hour, 2 hours and 6 hours following injection. These cumulative rates following DL-lactate administration were singnificantly lower for the first 40 minutes, compared with L-lactate and were only higher for the first 15 minutes, compared with acetate. These rates following DL-lactate administration were lower for doses of 1 mmol • kg^<-1> than for doses of 1μmol • kg^<-1> and also lower in fasting rats than in non-fasting animals. These phenomena were not observed for acetate.
departmental bulletin paper
Niigata University School of Medicine
1986-12
application/pdf
Acta medica et biologica
3
34
93
102
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6686/files/34(3)_93-102.pdf
eng