2024-03-28T15:11:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006667
2022-12-15T03:39:57Z
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471:537:568:653
Oral ingestion of syloid to mice ande rats and its chronic toxicity and carcinogenicity
Oral ingestion of syloid to mice ande rats and its chronic toxicity and carcinogenicity
Takizawa, Yukio
53872
Hirasawa, Fujiko
53873
Noritomi, Emiko
53874
Aida, Makiko
53875
Tsunoda, Hiroshi
53876
Uesugi, Shiro
53877
A long-term bioassay of chronic toxicity was conducted by orally administering the test material of food grade micronized silica, SYLOID (commercially produced by Fuji Davison Chemical Ltd., Japan), in a feed to B_6C_3F_1 mice and Fisher rats. The results of this study show that continuous dietary administration of SYLOID, at dose levels of 0, 1.25, 2.5, and 5%, to five-week-old specimens of both sexes for ca 93 consecutive weeks for mice and for ca 103 consecutive weeks for rats, causes no biological or any other meaningful alterations in body weight, food consumption, or physical features. No significant dose-related effects were seen at any dose level upon clinical laboratory examinations. Dietary administration of SYLOID to animals for the duration of a lifespan did not cause gross or microscopic changes in the tissues examined. The occasional presence of some neoplasms did not reveal any consistent, dose-related trends in any group. It may be concluded that proper dietary administration of micronized silica has proven to be generally safe with no long-term toxic effects.
departmental bulletin paper
Niigata University School of Medicine
1988-06
application/pdf
Acta medica et biologica
1
36
27
56
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6667/files/36(1)_27-56.pdf
eng