2024-03-28T22:48:53Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006630
2022-12-15T03:39:57Z
453:456
471:537:568:646
Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood
Plasma α_1-antichymotrypsin Activity in Renal Diseases of Childhood
Asami, Tadashi
53745
Nishihara, Touru
53746
Sakai, Kaoru
53747
To clarify the changes in plasma proteinase inhibitors in renal diseases, we measured the activity of plasma α_1-antichymotrypsin(α_1-Achy) under sueh conditions. The level of plasma α_1-Achy activity was found to be significantly lower in idiopathic nephrotic syndrome (INS) at relapse than in INS during remission, as well as in patients with chance proteinuria and/or hematuria (CPH) and in normal control subjects. The α_1-Achy activity in CPH was signiificantly elevated compared with that in INS (p<0.001) and normal controls (p<0.001). A significant inverse correlation was noted between the plasma α_1-Achy activity and the inhibitory effect of plasma on lymphocyte blastogenesis induced by Concanavalin A. Although the mechanism is unclear, the elevation of α_1-Achy in CPH (implicated in various types of glomerulonephritis) may be one of the responses of the body to counteract inflammatory processes by inactivating proteinase(s) released from infiltrating and/or proliferating cells in the glomeruli. The decreased plasma α_1-Achy level in INS may contribute to the depressed cellular immunity seen in INS.
departmental bulletin paper
Niigata University School of Medicine
1990-06
application/pdf
Acta medica et biologica
2
38
91
95
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6630/files/38(2)_91-95.pdf
eng