2024-03-28T10:43:59Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006606
2022-12-15T03:39:55Z
453:456
471:537:568:642
Increased Activity of Phasic Vasopressinergic Neurons in the Hypothalamic Paraventricular Nucleus, as Elicited by NaCl Injection into the Hepatic Portal Vein in the Rat
Increased Activity of Phasic Vasopressinergic Neurons in the Hypothalamic Paraventricular Nucleus, as Elicited by NaCl Injection into the Hepatic Portal Vein in the Rat
Sakaguchi, Takeo
53638
Okamura, Naotaka
53639
Miyaoka, Yozo
53640
Bando, Takehiko
53641
Magnocellular neurosecretory cells were antidromically identified in the hypothalamic paraventricular nucleus of urethane-anesthetized, ovariectomized female rats following electrical stimulation of the neurohypophysis. The vasopressinergic cells with a phasic pattern of spontaneous discharge and the oxytocinergic cells with a tonic pattern of discharge were distinguished and their response to hypo-, iso- and hypertonic NaCl solutions injected into the portal vein was examined. The hypertonic NaCl injection produced an increase in the discharge of vasopressinergic cells, while there was no appreciable change in the discharge after the hypo- and isotonic NaCl injections. The discharges in the oxytocinergic neurons were unchanged after these injections of NaCl. The stimulatory response in the vasopressinergic neurons caused by the hypertonic NaCl solution was not reproduced following hepatic branch vagotomy. Because neural discharge in the vasopressinergic cell has been shown to be linked to vasopressin secretion, these findings suggest that hypertonic hepatic vagus signals may modulate fluid balance through vasopressin at the paraventricular level.
departmental bulletin paper
Niigata University School of Medicine
1991-03
application/pdf
Acta medica et biologica
1
39
29
35
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6606/files/39(1)_29-35.pdf
eng