2024-03-28T13:43:23Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006588
2022-12-15T03:39:53Z
453:456
471:537:568:639
Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice
Effects of Kampohozais (Sho-saiko-to, Ninjin-to, Hochu-ekki-to and Juzen-taiho-to) on Immune Responses in Mice
Kaga, Hidetoshi
53591
Ochiai, Hiroshi
53592
Kurokawa, Masahiko
53593
Sakuragawa, Nobuo
53594
We have investigated the effects of Kampohozais (Traditional herbal drugs: Sho-saiko-to 小柴胡湯, Ninjin-to 人参湯, Hochu-ekki-to 補中益気湯,and Juzentaiho-to 十全大補湯) on immune responses in mice. Ninjin-to augmented the natural killer (NK) cell activity by a single intraperitoneal administration at doses of either 50, 100 or 200 mg/kg. Sho-saiko-to also augmented this activity at a dose of 100 mg/kg, but suppressed it at a dose of 200 mg/kg. An oral administration of Sho-saiko-to and Ninjin-to once a day at a dose of 250 mg/kg augmented the NK cell activity 7 and 20 days later, respectively. The effect of the remaining two Kampohozais was negligible. Four Kampohozais each exhibited a stronger mitogenic activity on B cell-rich population than on T cell-rich population, suggesting that these Kampohozais act as B cell mitogens. Treatment of mice with Sho-saiko-to by oral administration once a day for 13 days at a dose of 250 mg/kg increased the number of splenic antibody-producing cells against sheep erythrocytes, accompanied with an increase in both serum hemagglutinin and hemolysin titers.
departmental bulletin paper
Niigata University School of Medicine
1991-12
application/pdf
Acta medica et biologica
4
39
161
167
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6588/files/39(4)_161-167.pdf
eng