2024-03-29T10:35:55Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006524
2022-12-15T03:39:51Z
453:456
471:537:568:630
Extensive Epithelioid Cell Granulomatous Reactions to Esophageal and Gastric Carcinomas : Immunohistochemical Investigations of Four Cases
Extensive Epithelioid Cell Granulomatous Reactions to Esophageal and Gastric Carcinomas : Immunohistochemical Investigations of Four Cases
Nishimaki, Tadashi
53330
Ishihara, Noriko
53331
Watanabe, Hidenobu
53332
Tanaka, Otsuo
53333
Suzuki, Tsutomu
53334
Aizawa, Kikuo
53335
Hatakeyama, Katsuyoshi
53336
Muto, Terukazu
53337
Four cases of extensive epithelioid cell granulomatous reaction occurring in two gastric and two esophageal cancer patients are presented. Non-caseating epithelioid cell granulomas (NCEG) developed not only in the regional lymph nodes but within and widely around the primary tumor in all cases. NCEG also involved the spleen in one patient with early gastric cancer. The epithelioid cells directly infiltrated inside the tumor and obliterated cancer cells in one patient with esophageal cancer, the findings demonstrating histologic evidence that those cells have the ability to kill cancer cells. Three patients manifested the same immune alterations as those in sarcoidosis. Thus, NCEG associated with cancer are considered a morphological manifestation of the host immune response to cancer, most likely developing in the lymphoid organs. The extensive manifestation of such changes may develop under the altered immune conditions.
departmental bulletin paper
Niigata University School of Medicine
1993-09
application/pdf
Acta medica et biologica
3
41
155
162
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6524/files/41(3)_155-162.pdf
eng