2024-03-29T01:19:46Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006518
2022-12-15T03:39:51Z
453:456
471:537:568:629
Studies on Factors Affecting Plasma PIVKA-II Levels in Hepatocellular Carcinoma
Studies on Factors Affecting Plasma PIVKA-II Levels in Hepatocellular Carcinoma
Soga, Kenji
53304
Arai, Futoshi
53305
Tsuruya, Takashi
53306
Aikawa, Keiko
53307
Toshima, Muneatsu
53308
Shibasaki, Koichi
53309
Aoyagi, Yutaka
53310
In order to diagnose hepatocellular carcinoma (HCC), plasma levels of protein induced by vitamin K absence or antagonist-II (PIVKA-II) were determined by an enzyme-linked immunosorbent assay (ELISA). Positive reaction was noted in 34 (68%) of 50 patients with HCC, with PIVKA-II serving as an useful tumor marker in the estimation of HCC staging. On the other hand, the administration of vitamin K and the presence of jaundice were found to be important factors that affect plasma PIVKA-II levels. The administration of antibiotics with N-methylthiotetrazole at a dosage of 2 g/day for 3 days (total 6 g) did not seem to increase plasma concentrations of PIVKA-II levels. Thus, the measurement of the plasma PIVKA-II levels was useful for the diagnosis of HCC except for the disturbance of vitamin K utilization.
departmental bulletin paper
Niigata University School of Medicine
1993-12
application/pdf
Acta medica et biologica
4
41
197
200
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6518/files/41(4)_197-200.pdf
eng