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2022-12-15T03:39:44Z
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Responses Evoked by the Pharyngolaryngeal Application of Saline in Vasopressinergic Cells
Responses Evoked by the Pharyngolaryngeal Application of Saline in Vasopressinergic Cells
Akaishi, Takao
53042
Homma, Shinji
53043
pharyngolarynx
saline
vasopressin
rat
The roles of the pharynx and larynx in body water regulation were studied in the urethane-anesthetized (1.2g/kg, b.wt.) rat by recording the electrical activities of supraoptic vasopressin (AVP) producing cells in the hypothalamus. The pharyngo/laryngeal application of 0.15ml/kg b.wt. water caused a decrease in the electrical activity of the AVP producing cell, whereas 0.3 M saline caused an increase in the firing activity. Isotonic saline had no effect, nor did applications of 0.3 M saline to the dorsal tongue. Application of 0.05 mM amiloride, a gustatory sodium antagonist, caused a decrease in the firing activity. Hypertonic saline (0.3 M) containing 0.05 mM amiloride caused an insignificant change in their activity. Isotonic saline in amiloride had no effect. The pharyngeal application of 0.3 M choline chloride had also no effect on the firing activity of the AVP producing cells. These data suggest the following points: 1) afferents from oropharyngeal and laryngeal mucosa regulate the activity of AVP cells; 2) these afferents are influenced by the concentration of sodium chloride involved in the ingested solution; and 3) the gustatory reception of sodium is involved in this mechanism.
departmental bulletin paper
Niigata University School of Medicine
1995-09
application/pdf
Acta medica et biologica
3
43
121
126
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6460/files/43(3)_121-126.pdf
eng