2026-03-12T20:37:04Z https://niigata-u.repo.nii.ac.jp/oai

oai:niigata-u.repo.nii.ac.jp:00006455 2022-12-15T03:39:45Z 453:456 471:537:568:621

Immunological Effects of Lumin-A, a Fluorescent Antioxidant Drug, on T Cell Subsets in Various Immune Organs of Mice Immunological Effects of Lumin-A, a Fluorescent Antioxidant Drug, on T Cell Subsets in Various Immune Organs of Mice Ohtsuka, Kazuo 53018 Yamamura, Soichiro 53019 Osman, Yasser 53020 Arai, Katsumitsu 53021 Hasegawa, Katsuhiko 53022 Yamagiwa, Satoshi 53023 Nakayama, Mauro 53024 Abo, Toru 53025 lumin-A antioxidant drug extrathymic T cell thymus-derived T cell It is important to determine how fluorescent antioxidant drugs act as immunomodulators. Since a new T-cell population, namely, extrathymic T cells, has recently been identified in the liver and other immune organs, our attention was focused on how one of the above-mentioned drugs (Lumin-A in this study) affects the distribution of extrathymic T cells and thymus-derived T cells in various immune organs. When Lumin-A was administered into mice daily (10 μg/mouse/day) with intraperitoneal or oral route for 3 wks, its unique effect was observed, depending on the routes. Especially, the oral ad libitum administration of Lumin-A induced a prominent induction of thymus-derived T cells, but not extrathymic T cells, in the peripheral immune organs, the spleen and the liver. The present results suggest that a fluorescent antioxidant drug, Lumin-A, has an ability to induce the thymus-derived T cells, i.e., usual T cells for processing foreign antigens, into the periphery. departmental bulletin paper Niigata University School of Medicine 1995-12 application/pdf Acta medica et biologica 4 43 205 209 Acta medica et biologica AA00508361 05677734 https://niigata-u.repo.nii.ac.jp/record/6455/files/43(4)_205-209.pdf http://hdl.handle.net/10191/33218 https://niigata-u.repo.nii.ac.jp/records/6455 eng