2024-03-29T13:36:37Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006427
2022-12-15T03:39:43Z
453:456
471:537:568:618
Radiosensitization of FM3A Cells by 5-Fluorouracil Plus Cisplatin
Radiosensitization of FM3A Cells by 5-Fluorouracil Plus Cisplatin
Higuchi, Shoichi
52862
Fujita, Shozo
52863
Sueyama, Hiroo
52864
Ohkubo, Masaki
52865
Sakai, Kunio
52866
radiation
5-ftuorouracil
cisplatin
FM3A cells
radiosensitization
The effects of radiation in combination with either 5-fluorouracil (5-FU), cisplatin (CDDP), or both on FM3A cell survival were evaluated in vitro. Cell survival following treatment with the drugs and/or radiation was determined by colony formation assays. Prolonged exposure of 5-FU as well as CDDP was very effective in killing cells. The combination of radiation with 24-hour continuous exposure of the drugs resulted in radiosensitization, while 1-hour pulse exposure of CDDP combined with radiation did not enhance cell killing, indicating that radiosensitization by CDDP may require a longer duration of drug exposure following irradiation. In addition, concurrent continuous exposure of 5-FU and CDDP in combination with radiation resulted in a greater radiosensitizing effect.
departmental bulletin paper
Niigata University School of Medicine
1996-09
application/pdf
Acta medica et biologica
3
44
141
145
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6427/files/44(3)_141-145.pdf
eng