2024-03-29T09:04:46Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006406
2022-12-15T03:39:41Z
453:456
471:537:568:615
Effects of Dietary Factors (Fat and Fiber) on Experimental Colon Carcinogenesis and Cancer Growth in Rats
Effects of Dietary Factors (Fat and Fiber) on Experimental Colon Carcinogenesis and Cancer Growth in Rats
Endo, Kazuhiko
52749
Hatakeyama, Katsuyoshi
52750
Soga, Jun
52751
Muto, Terukazu
52752
1,2-dimethylhydrazine (DMH)
experimental colon cancer
dietary factors
fat
fiber
The effects of dietary fat and fiber on colonic carcinogenesis and tumor growth in rats were assessed. Over a period of 30 weeks, four groups of 10 animals were fed diets with: high fat and high fiber content; high fat content and no fiber; no fat and high fiber content; or no fat and no fiber. Five weeks after starting these diets, each group was divided into two subgroups, one receiving 10 weekly injections of the carcinogen 1, 2-dimethylhydrazine (DMH); (20 mg/kg/ week). The other (control) subgroups recieved no DMH. At 30 weeks the rats were killed and autopsies were performed. Results showed cancers were limited to rats receiving DMH. The average numbers of cancers per rat were 4.8±2.6 for the high fat and fiber group; 6.2± 4.6 for the high fat, no fiber group; 2.3± 1.5 for no fat, high fiber; and 2.2±0.8 for no fat, no fiber. High-fat animals tended to have more DMH-induced cancers than no-fat animals. Aggregate cancer volume per rat was smallest for the no-fat, high-fiber diet.
departmental bulletin paper
Niigata University School of Medicine
1997-06
application/pdf
Acta medica et biologica
2
45
69
73
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6406/files/45(2)_69-73.pdf
eng