2024-03-28T09:00:40Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006359
2022-12-15T03:39:40Z
453:456
471:537:568:608
Platelet and Cholesterol Responses Caused by Oral Administration of Ginseng Extract in 66% Hepatectomized Rats
Platelet and Cholesterol Responses Caused by Oral Administration of Ginseng Extract in 66% Hepatectomized Rats
CUI, Xing
52538
SAKAGUCHI, Takeo
52539
OHTAKE, Masahiro
52540
SHIRAI, Yoshio
52541
HATAKEYAMA, Katsuyoshi
52542
major abdominal surgery
hepatic resection
ginseng delivery
platelet
cholesterol
postoperative complications
Platelet counts and serum cholesterol levels in the blood were examined after oral administration of ginseng extract (GE) to 66% hepatectomized rats. A significant decrease in the platelet count (PC) and adhesiveness (PA) was obtained 3 days after hepatectomy when GE 125 mg/kg/day was administered, and the PA reduction was dose dependent in the range of 0-250 mg/kg/day. The serum concentration of total cholesterol was also decreased by the GE administration, but food intake was unaffected. Serum parameters indicating liver and kidney functions were unchanged after GE administration except for lipid metabolic parameters. Because enhanced PC and PA in the presence of hypercholesterolemia are apt to lead to thromboembolism after major abdominal surgery, these results suggest that orally administered GE is capable of preventing the thromboembolic tendency associated with major hepatic surgery.
departmental bulletin paper
Niigata University School of Medicine
1999-03
application/pdf
Acta medica et biologica
1
47
15
19
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6359/files/KJ00000007195.pdf
eng