2024-03-28T20:15:57Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006349
2022-12-15T03:39:39Z
453:456
471:537:568:606
Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency
Allogeneic Transplantation of CD34^+ Peripheral Blood Progenitor Cells for Severe Combined Immunodeficiency
WATANABE, Akihiro
52490
KAKIHARA, Toshio
52491
KANTO, Kazunari
52492
YAMAMOTO, Kohsuke
52493
TANAKA, Atsushi
52494
NUMATA, Osamu
52495
TORIGOE, Katsumi
52496
TOBA, Ken
52497
UCHIYAMA, Makoto
52498
severe combined immunodeficiency
cytomegaloviral pneumonitis
mismatched HLA
allogeneic peripheral blood stem cell transplantation
CD34^+ cells purification
Severe combined immunodeficiency (SCID) is a fatal congenital disorder of the immune system for which the only curative treatment is the reconstitution of the immune system by stem cell transplantation. In the case reported here we attempted the allogeneic transplantation of purified CD34^+ cells derived from granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood of the HLA-haploidentical father for a three-month-old female SCID patient, in whom both T and B cells were absent, but natural killer (NK) cells were present. Her father was administered with G-CSF (10μg/kg/day) subcutaneously for four days, and a total number of 2.3×10^7 (=4.6×10^6/kg of patient's body weight) CD34^+ cells was harvested. Purified CD34^+ cells were transplanted into the patient without preconditioning. A skin rash consistent with graft-versushost disease (GVHD) was observed on day 10 after transplantation. CD3^+ cells appeared in the peripheral blood on day 14. These findings indicate that allogeneic transplantation of purified CD34^+ cells could be one useful treatment option for SCID patients, although data from a greater number of patients will be required to draw definitive conclusions.
departmental bulletin paper
Niigata University School of Medicine
1999-09
application/pdf
Acta medica et biologica
3
47
115
120
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6349/files/KJ00000007218.pdf
eng