2024-03-28T14:23:53Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006342
2022-12-15T03:39:39Z
453:456
471:537:568:605
Renal Hemodynamic Characteristics and Their Correlation with Serum Autoantibodies in Patients with Systemic Sclerosis
Renal Hemodynamic Characteristics and Their Correlation with Serum Autoantibodies in Patients with Systemic Sclerosis
NAKANO, Masaaki
52462
OHUCHI, Yuko
52463
HASEGAWA, Hisashi
52464
KURODA, Takeshi
52465
ITO, Satoshi
52466
ARAKAWA, Masaaki
52467
systemic sclerosis
renal hemodynamics
anti-DNA topoisomerase 1 antibody
anti-centromere antibody
renal plasma flow
filtration fraction
To clarify the characteristics of renal hemodynamics and their correlation with serum autoantibodies in patients with systemic sclerosis (SSc). Methods : Glomerular filtration rate (GFR) and renal plasma flow (RPF) were analyzed retrospectively in three groups totaling 50 Japanese patients with SSc treated between 1982 and 1998. The filtration fraction (FF) was calculated from the values obtained for GFR and RPF (GFR/RPF). The presence of antibodies to DNA topoisomerase 1 (A-Topo) and centromere (ACA) were also examined in relation to renal hemodynamics. Results : The GFR was abnormally low in 8 (16.0%) patients, but a decreased RPF was observed in 21 (42.0%). Thus, an increased FF was frequently observed (29/50; 58.0%). A-Topo was detected in 23 patients (group A) and ACA in 10 (group B). In the remaining 17 patients (group C), however, these autoantibodies were not detected. Diffuse scleroderma or pulmonary fibrosis was more prevalent in group A than in group B. The mean GFR in group B was significantly lower than that in group C. The mean RPF in group B was significantly lower than that in the other 2 groups. Patients with an increased FF were more often found in group B than in the other 2 groups. Conclusions : A reduction in RPF disproportionate to the reduction in GFR, as demonstrated by the high FF, was observed frequently in SSc patients. Although ACA was associated with less serious cutaneous or pulmonary involvement, renal hemodynamic alterations seemed to correlate with the presence of ACA.
departmental bulletin paper
Niigata University School of Medicine
1999-12
application/pdf
Acta medica et biologica
4
47
155
159
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6342/files/KJ00000007228.pdf
eng