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2022-12-15T03:39:38Z
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Alterations in the Expression of Intercellular Adhesion Molecule-1(ICAM-1) on Neutrophils and in the Serum in the Coronary Circulationof Patients with Coronary Artery Disease
Alterations in the Expression of Intercellular Adhesion Molecule-1(ICAM-1) on Neutrophils and in the Serum in the Coronary Circulationof Patients with Coronary Artery Disease
HIGUCHI, Kotaro
52315
MATSUBARA, Taku
52316
TOBA, Ken
52317
HORI, Tomoyuki
52318
IDA, Toru
52319
TAKEMOTO, Minoru
52320
TAMURA, Yusuke
52321
YAMAZOE, Masaru
52322
OITE, Takashi
52323
AIZAWA, Yoshifusa
52324
ICAM-1
coronary artery disease
coronary circulation
The intercellular adhesion molecule-1 (ICAM-1) is expressed on the surface of endothelial cells as well as neutrophils. Because neutrophils in the coronary circulation may play an important role in the progression of coronary artery disease, ICAM-1 and other adhesion molecules expressed on them were studied in the coronary circulation of patients with coronary artery disease. We used flow cytofluorometry to evaluate the amount of ICAM-1,CD18,and L-selectin expressed on neutrophils entering and leaving the coronary circulation in 18 patients who underwent coronary angiography. In addition, the serum level of the circulating form of ICAM-1 (cICAM-1) was measured in the same samples by using an enzyme-linked immunosorbent assay. Expression as the percentage of change between the left coronary artery and coronary sinus showed that neutrophil ICAM-1 (nICAM-1) decreased and serum cICAM-1 increased in patients with severe left coronary artery stenosis, compared with those with angiographically normal coronary arteries or only mild stenosis (nICAM-1,-9.7±2.9% vs 1.0±4.0%, p<0.05; cICAM-1,6.3±1.9% vs 0.5±1.7%, p<0.05,respectively). The changes in the expression of CD18 and L-selectin on neutrophils passing through the coronary circulation were not significant (CD18,-3.1±2.0% vs -3.8±4.3%; L-selectin, 6.0±3.6% vs -1.5±4.5%, respectively). ICAM-1 expressed on neutrophils appeared to be digested and relesed into plasma during passage through the coronary circulation in patients with severe stenotic coronary arteries. Thus, measurements of ICAM-1 may allow a prediction of the progression of coronary atherosclerosis.
departmental bulletin paper
Niigata University School of Medicine
2000-12
application/pdf
Acta medica et biologica
4
48
119
125
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6317/files/KJ00000007272.pdf
eng