2024-03-29T04:51:50Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006302
2022-12-15T03:39:37Z
453:456
471:537:568:598
Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes
Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes
ITO, Yumi
52230
MORIOKA, Yoshio
52231
KOIKE, Hiroko
52232
IKEZUMI, Yohei
52233
KOBAYASHI, Hideo
52234
GEJYO, Fumitake
52235
SHIMIZU, Fujio
52236
KAWACHI, Hiroshi
52237
Thy 1.1. nephritis
mAb 1-22-3
ED3
MCP-1
We compared the acute phase responses of mesangial cells and inflammatory cells in reversible and irreversible mesangial alterations. We used a reversible model that induced by a single injection of anti-Thy 1.1 monoclonal antibody (mAb) 1-22-3,and an irreversible model of glomerulonephritis induced by two consecutive injections of mAb 1-22-3 with an interval of 2 weeks. Similar mesangiolysis occurred in both models. However, pathological phenotypic changes in the mesangial cell began more rapidly and markedly after the second wave of mesangiolysis. Glomerular mRNA expression of platelet-derived growth factor (PDGF) was higher in the irreversible model than in the reversible model, whereas mRNA expression of monocyte chemoattractant protein-1 (MCP-1) was lower in the irreversible model. The numbers of polymorphonuclear cell (PMN) and ED1^+ monocytes/macrophages were lower in the irreversible model than in the reversible model. By contrast, the recruitment of ED3^+ cells into the glomeruli was dominant in the irreversible model. A dual labeling study showed that major parts of ED3^+ cells in the glomeruli of the irreversible model were ED1 negative. ED3^+ ED1^- cells were not detected at any time in the reversible model. The ED3^+ cell should be regarded as an important candidate for acting on the mesangial cell to lead to irreversible mesangial alterations.
departmental bulletin paper
Niigata University School of Medicine
2001-09
application/pdf
Acta medica et biologica
3-4
49
73
80
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6302/files/KJ00001015037.pdf
eng