2024-03-28T20:41:12Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00006287
2022-12-15T03:39:37Z
453:456
471:537:568:595
Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation
Difference of Cyclosporin A and Endothelin-1 Concentrations between a Patient with Hypertension and without Hypertension after Allogeneic Bone Marrow Transplantation
SEKI, Yoshinobu
52125
FURUKAWA, Tatsuo
52126
YUASA, Kazuhisa
52127
KOIKE, Tadashi
52128
AIZAWA, Yoshifusa
52129
Cyclosporin A
endothelin-1
hypertension
bone marrow transplantation
Background. Cyclosporin-induced hypertension is considered to be a result of elevated plasma endothelin-1 (ET-1) oo sodium retention. Methods. To evaluate the function and the degree of vascular damage of endothelial cells in cyclosporininduced hypertension after allogeneic bone marrow transplantation (BMT), we continuously measured blood pressure by ambulatory blood pressure monitoring and measured plasma levels of endothelin-1 and soluble thrombomodulin (TM) together with cyclosporin A (CsA) concentration. Results. CsA level was the lowest one hour after the administration of CsA and peaked 4-6 hours after it. ET-1 levels had a similar profile to CsA levels. No change in TM levels was observed. Systolic blood pressure levels were over 140 mmHg throughout the day, and tended to rise further degree 3-4 hours after the ET-1 level rose. The presence of an immediate change in systolic blood pressure associated with ET-1 change was unclear. In contrast, another patient who had normal ET-1 levels and low concentration levels of CsA showed normal blood pressure. Conclusions. ET-1 is released from endothelial cells, probably due to cyclosporin, and may contribute to cyclosporin-induced hypertension after BMT.
departmental bulletin paper
Niigata University School of Medicine
2002-09
application/pdf
Acta medica et biologica
3
50
157
160
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6287/files/KJ00000007335.pdf
eng