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Occurrence of a Vibrio vulnificus Infection in Niigata in 2003
Occurrence of a Vibrio vulnificus Infection in Niigata in 2003
SHIBUYA, Michiko
51988
ITO, Ryo
51989
TAKIZAWA, Yoko
51990
TANEIKE, Ikue
51991
NAKAGAWA, Saori
51992
IWAKURA, Nobuhiro
51993
NAKAYAMA, Teruko
51994
ANNO, Masato
51995
YAGI, Yutaka
51996
YAMAMOTO, Tatsuo
51997
Vibrio vulnificus
infection case in Niigata
drug susceptibility
adherence
bacterial cell shape
A Vibrio vulnificus infection occurred in Niigata in 2003. The patient was a 76-year-old male who had a medical history of diabetes, and was a heavy consumer of alcohol. He did not eat raw fish or shellfish before development of the symptoms, and the source of infection was unknown. The patient reported a disturbance in consciousness, and mild swelling of the lower leg was observed. The same V. vulnificus strains, as evidenced by pulsed-field gel electrophoresis, were isolated from venous blood and puncture fluid of the lower leg. White blood cells and platelets were decreased. The patient was treated with imipenem, but succumbed. The V. vulnificus strains were highly susceptible to the 3rd-generation cephems, carbapenems, tetracyclines, and fluoroquinolones. With respect to the tetracyclines and macrolides, the strains were most susceptible to minocycline and azithromycin, respectively. The strains were moderately resistant to the 1st- and the 2nd- generation cephems, kanamycin, streptomycin, roxithromycin, and fosfomycin. The V. vulnificus strains possessed a strong ability to adhere to and impair HCT-8 cells. In contrast to V. cholerae O1 or O139 and V. parahaemolyticus, the V. vulnificus strains had capsule-like wrinkles on the bacterial cell surface and occasionally exhibited a spiral-shaped body. These may be a cause, at least in part, of the invasive nature of the bacteria and fulminant development of the symptoms. Establishment of a rapid diagnosis is imperative.
departmental bulletin paper
Niigata University School of Medicine
2003-12
application/pdf
Acta medica et biologica
4
51
149
156
Acta medica et biologica
AA00508361
05677734
https://niigata-u.repo.nii.ac.jp/record/6261/files/KJ00004267698.pdf
eng