2024-03-29T08:37:41Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00005957
2022-12-15T03:39:13Z
453:455
471:561:562
2型糖尿病患者におけるうつ症状重症度と全死因死亡の関係に関する検討
Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS)
Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS)
Matsunaga, Satoshi
51147
Diabetes mellitus, type 2
Depressive disorder
Death
Hypoglycemia
新潟大学
博士(医学)
Objective: The aims of this study are to confirm whether the excess mortality caused by depressive symptoms is independent of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and to evaluate the association between all-cause mortality and degrees of severity of depressive symptoms in Japanese patients with T2DM. Methods: A total of 1160 Japanese patients with T2DM were eligible for this analysis. Participants were followed prospectively for 3 years and their depressive states were evaluated at baseline by the Center for Epidemiologic Studies Depression Scale (CES-D). Cox proportional hazards model was used to evaluate the relative risk of allcause mortality and was adjusted by possible confounding factors, including severe hypoglycemia, all of which are known as risk factors for both depression and mortality. Results: After adjustment for severe hypoglycemia, each 5-point increase in the CES-D score was significantly associated with excess all-cause mortality (hazard ratio 1.69 [95% CI 1.26.2.17]). The spline curve of HRs for mortality according to total CES-D scores showed that mortality risk was slightly increased at lower scores but was sharply elevated at higher scores. Conclusion: A high score on the CES-D at baseline was significantly associated with all-cause mortality in patients with T2DM after adjusting for confounders including severe hypoglycemia. However, only a small effect on mortality risk was found at relatively lower levels of depressive symptoms in this population. Further research is needed to confirm this relationship between the severity of depressive symptoms and mortality in patients with T2DM.
学位の種類: 博士(医学). 報告番号: 甲第4361号. 学位記番号: 新大院博(医)甲第774号. 学位授与年月日: 平成29年9月20日
Journal of Psychosomatic Research. 2017, 99, 34–39.
新大院博(医)甲第774号
thesis
新潟大学
2017-09-20
2017-09-20
application/pdf
application/pdf
13101甲第4361号
https://niigata-u.repo.nii.ac.jp/record/5957/files/h29nmk774.pdf
https://niigata-u.repo.nii.ac.jp/record/5957/files/h29nmk774_a.pdf
eng
info:doi/10.1016/j.jpsychores.2017.05.020
(C) 2017 Elsevier Inc. All rights reserved.