2024-03-29T07:20:42Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00004402
2022-12-15T03:37:14Z
453:455
471:561:562
Magnetic Resonance Study on the Erythrocytes from Myotonic Dystrophy
筋緊張性ジストロフィー症患者赤血球の磁気共鳴法による研究
筋緊張性ジストロフィー症患者赤血球の磁気共鳴法による研究
桑原, 武夫
48384
MRS
myotonic dystrophy
erythrocyte
water permeability
Na pump
glycolysis
磁気共鳴スペクトロスコピー
筋緊張性ジストロフィー症
赤血球
水交換
ナトリウムポンプ
糖代謝
新潟大学
博士(医学)
We have studied the water permeability through membranes, the function of the Na pump, and glucose metabolism of erythrocytes of patients with myotonic muscular dystrophy (MyD) using 1H-, 23Na, and 13C-magnetic resonance spectroscopy (MRS). A significant decrease in water permeability was recognized in the MyD erythrocyte meinbrane, and impared Na pumping was suspected to be correlated with the former biochemical abnormalities in hand III protein of MyD erythrocyte membrane. Significant acrelation of glycolysis in erythrocyte for the first 160 minutes was also recognized in MyD however, the production of lactate showed no difference between MyD and controls. The increased glucose uptake in MyD may be compensatory to the diminished pumping mechanism, but further information, such as inorganic phosphate permeability and the activity of the rate-limiting enzyme of erythrocyte glycolysis is needed.
学位の種類: 博士(医学). 報告番号: 乙第1234号. 学位記番号: 新大博(医)乙第1149号. 学位授与年月日: 平成4年3月3日
新潟医学会雑誌. 1992, 106(6), 563-572.
新大博(医)乙第1149号
thesis
新潟大学
1992-03-03
1992-03-03
application/pdf
1
37
13101B1234
https://niigata-u.repo.nii.ac.jp/record/4402/files/000000251493.pdf
jpn