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Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats
Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats
Kose, Hiroyuki
4800
Sado, Yoshikazu
4801
Yamada, Takahisa
4802
Matsumoto, Kozo
4803
glomerulonephritis
QTL
analysis
WKY rat
Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F1 (WKY × DA) × WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed.
journal article
Japanese Association for Laboratory Animal Science
2009-12
application/pdf
Experimental animals
2
58
193
198
Experimental animals
AA11032321
13411357
https://niigata-u.repo.nii.ac.jp/record/1651/files/58_2_193-198.pdf
eng
info:doi/10.1538/expanim.58.193
https://www.jstage.jst.go.jp/article/expanim/58/2/58_2_193/_pdf
Copyright(C)2009 Japanese Association for Laboratory Animal Science
本文データは学協会の許諾に基づきJ-Stageから複製したものである