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On the cyclization mechanism of squalene : a ring expansion process of the five-membered D-ring intermediate
On the cyclization mechanism of squalene : a ring expansion process of the five-membered D-ring intermediate
Sato, Tsutomu
4614
Hoshino, Tsutomu
4615
Abe, Takamasa
4616
Site-directed mutagenesis experiments with W169F, W169H and W489F for the squalene-hopene cyclase, and the formation of 10 possessing the five-membered D-ring and a tetrahydrofuran moiety as the enzyme product of the analogue 8 with a hydroxy group, strongly suggest that a ring expansion reaction from the five- to the six-membered ring is responsible for the D-ring formation of hopene.
journal article
Royal Society of Chemistry
1998-12
application/pdf
Chemical communications
23
1998
2617
2618
Chemical communications
AA11071130
13597345
https://niigata-u.repo.nii.ac.jp/record/1616/files/1998_2617-2618.pdf
eng
info:doi/10.1039/A806948D