2024-03-29T15:07:19Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:02000963
2023-04-27T02:14:26Z
453:455
471:561:562
Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function
水素型小腸内細菌異常増殖は肝性脳症や肝機能と関連する
Yokoyama, Kunihiko
横山, 邦彦
open access
© 2022 Yokoyama et al.
Creative Commons Attribution 4.0 International
Overt hepatic encephalopathy (HE) is one of the complications of liver cirrhosis (LC), which negatively affects the prognosis and quality of life of patients. Small intestinal bacterial overgrowth (SIBO) is significantly associated with LC and its complications, including HE. We investigated the relationship between SIBO and LC, and the difference between hydrogen-producing and methane-producing SIBO (H-SIBO and M-SIBO, respectively). This is a prospective cohort study of 107 cases. Breath measurements of hydrogen and methane concentrations were performed for the diagnosis of SIBO. The study cohort included 81 males with a median age of 70 (40-86) years, and SIBO was detected in 31 cases (29.0%). There were no significant differences between the SIBO positive and SIBO negative groups. Reclassification into H-SIBO (16 cases) and others (91 cases) was performed, and the Child-Pugh score was only derived in the multivariate logistic analysis (P=0.028, odds ratio 1.39, 95% confidence interval 1.04-1.85). Furthermore, H-SIBO was significantly associated with covert HE in chi-square test (50.0% vs. 24.2%, P=0.034). In addition, we evaluated the therapeutic response on SIBO of rifaximin in eight covert HE patients. 20% patients with M-SIBO and 67% patients with H-SIBO showed an improvement of the breath test. In conclusion, H-SIBO, but not M-SIBO, is significantly associated with liver function, and rifaximin might be more effective for covert HE with H-SIBO. Therefore, the diagnosis of SIBO, including the classification as H-SIBO and M-SIBO, might help to determine the choice of treatment for HE.
PLoS ONE. 2022, 17(2), e0264459.
新大院博(医)第1084号
eng
doctoral thesis
http://hdl.handle.net/10191/0002000963
https://niigata-u.repo.nii.ac.jp/records/2000963
https://doi.org/10.1371/journal.pone.0264459
甲第5071号
博士(医学)
2022-09-20
13101
新潟大学
Niigata University
https://niigata-u.repo.nii.ac.jp/record/2000963/files/r4nmk1084.pdf
application/pdf
901KB
2023-04-27
https://niigata-u.repo.nii.ac.jp/record/2000963/files/r4nmk1084_a.pdf
application/pdf
435KB
2023-04-27