2024-03-29T09:15:30Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00032098
2022-12-15T04:07:43Z
453:455
471:561:562
Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010-2015
Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010-2015
2010年から2015年においてミャンマーで流行したヒトインフルエンザA型およびB型の系統地理学的解析
Htwe, Khin Thu Zar
【○!C】2019 Htwe et al.
We investigated the circulation patterns of human influenza A and B viruses in Myanmar between 2010 and 2015 by analyzing full HA genes. Upper respiratory tract specimens were collected from patients with symptoms of influenza-like illness. A total of 2,860 respiratory samples were screened by influenza rapid diagnostic test, of which 1,577 (55.1%) and 810 (28.3%) were positive for influenza A and B, respectively. Of the 1,010 specimens that were positive for virus isolation, 370 (36.6%) were A(H1N1)pdm09, 327 (32.4%) were A(H3N2), 130 (12.9%) B(Victoria), and 183 (18.1%) were B(Yamagata) viruses. Our data showed that influenza epidemics mainly occurred during the rainy season in Myanmar. Our three study sites, Yangon, Pyinmana, and Pyin Oo Lwin had similar seasonality and circulating type and subtype of influenza in a given year. Moreover, viruses circulating in Myanmar during the study period were closely related genetically to those detected in Thailand, India, and China. Phylogeographic analysis showed that A(H1N1)pdm09 viruses in Myanmar originated from Europe and migrated to other countries via Japan. Similarly, A (H3N2) viruses in Myanmar originated from Europe, and disseminated to the various countries via Australia. In addition, Myanmar plays a key role in reseeding of influenza B viruses to Southeast Asia and East Asia as well as Europe and Africa. Thus, we concluded that influenza virus in Myanmar has a strong link to neighboring Asian countries, Europe and Oceania.
学位の種類: 博士(医学). 報告番号: 甲第4563号. 学位記番号: 新大院博(医)甲第885号. 学位授与年月日: 平成31年3月25日
新大院博(医)甲第885号
新潟大学
2019-03-25
eng
thesis
http://hdl.handle.net/10191/51301
https://niigata-u.repo.nii.ac.jp/records/32098
13101甲第4563号
博士(医学)
2019-03-25
新潟大学
https://niigata-u.repo.nii.ac.jp/record/32098/files/h30nmk885.pdf
application/pdf
4.0 MB
2020-05-20
https://niigata-u.repo.nii.ac.jp/record/32098/files/h30nmk885_a.pdf
application/pdf
773.6 kB
2019-09-10