2024-03-29T14:31:38Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00032016
2022-12-15T04:02:21Z
453:455
471:561:562
Different distribution of mucosal-associated invariant T cells within the human cecum and colon
Different distribution of mucosal-associated invariant T cells within the human cecum and colon
盲腸と結腸の粘膜におけるMAIT細胞に関する検討
Hama, Isamu
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are involved in anti-bacterial immunity. MAIT cells are found in the intestine, but their role and distribution within the large intestine have not been fully elucidated. Therefore, we investigated the distribution of MAIT cells within the cecum and colon. Surgically resected tissues of the cecum and colon were obtained from 4 patients with cecal appendix cancer and 8 patients with colorectal cancer, respectively. Lymphocytes were isolated from the intestinal epithelium (intraepithelial lymphocytes, IELs) and the underlying lamina propria (lamina propria lymphocytes, LPLs), and then, MAIT cells were analyzed by flow cytometry. Compared with the colon, the cecum showed a significantly increased frequency of MAIT cells among IELs (P<0.01). CD69 expression on MAIT cells was significantly increased in the cecum and colon compared with that in the blood, and the frequency of natural killer group 2, member A^+ cells among MAIT cells was significantly increased in the cecum. These results suggest that the distribution of MAIT cells was different between the cecum and colon and that MAIT cells were more likely to be activated, especially in the intestinal epithelium of the cecum than in the colon and blood.
学位の種類: 博士(医学). 報告番号: 甲第4490号. 学位記番号: 新大院博(医)甲第827号. 学位授与年月日: 平成30年9月20日
新大院博(医)甲第827号
新潟大学
2018-09-20
eng
thesis
http://hdl.handle.net/10191/50777
https://niigata-u.repo.nii.ac.jp/records/32016
1
29
13101甲第4490号
博士(医学)
2018-09-20
新潟大学
https://niigata-u.repo.nii.ac.jp/record/32016/files/h30nmk827.pdf
application/pdf
722.4 kB
2019-09-10
https://niigata-u.repo.nii.ac.jp/record/32016/files/h30nmk827_a.pdf
application/pdf
522.9 kB
2019-09-10