2024-03-29T08:36:28Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00022877
2022-12-15T03:53:11Z
453:456
471:537:538:1209
抗プロゲステロン剤, RU38486の妊娠ラットに対する流産誘発機序に関する研究
抗プロゲステロン剤, RU38486の妊娠ラットに対する流産誘発機序に関する研究
Studies on the Antireproductive Mechanism of RU38486, an Antiprogesterone Agent, to Pregnant Rats
西村, 満
RU38486
anti-implantation
abortion
decidua
着床阻害
流産
脱落膜
Effects of antiprogesterone (RU38486) were studied in pregnant rats. This synthetic compound (5, 10mg/kg) induced complete abortion when it was administered (p. o.) on day 8, 9, 10, 11, 12, 13 postconception. The anti-implantation effects were decreased when administered on day 6, 7 especially in cases of 5mg/kg. As to the anti-implantation effects, complete block was seen in all cases when 10mg/kg was given to the rats. Serial macroscopical and histological studies were carried out and its antiprogestational activity was demonstrated on the decidual capillary and cells prior to the changes of progesterone level. Changes of trophoblast were not remarkable, and no immunological effects were shown in decidual area. These data suggest that anti-implantational and abortificient action of RU38486 mainly consists in the uterine endometrial (decidual) level.
新潟医学会
1989-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/41291
https://niigata-u.repo.nii.ac.jp/records/22877
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
103
6
472
479
https://niigata-u.repo.nii.ac.jp/record/22877/files/103(6)_472-479.pdf
application/pdf
3.7 MB
2019-08-19