2024-03-29T13:27:59Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00022871
2022-12-15T03:53:08Z
453:456
471:537:538:1209
2) Myelin-associated glycoprotein (MAG) 遺伝子の解析とその応用(シンポジウム 遺伝子工学による病因解析とその診断, 第435回新潟医学会)
2) Myelin-associated glycoprotein (MAG) 遺伝子の解析とその応用(シンポジウム 遺伝子工学による病因解析とその診断, 第435回新潟医学会)
cDNA Cloning of MAG and its Application for Study on Myelination.(Molecular Genetic Approaches to Human Diseases)
藤田, 信也
佐藤, 修三
宮武, 正
栗原, 正
高橋, 康夫
myelin-associated glycoprotein
mRNA
alternative splicing
quaking mouse
The myelin-associated glycoprotein (MAG) is a quantitatively minor component of the myelin sheath, but it may play a regulatory role in myelinogenesis. We have isolated a cDNA clone for mouse MAG from an expression library using polyclonal antisera against mouse MAG. The clone was found to contain 1350nt cDNA, and the sequenced regions were homologous to the corresponding regions of the previousely reported rat MAG cDNA. Evidence is presented that expression of the two MAG mRNAs is developmentally regulated in mouse brain. In the quaking mouse, the mRNA without a 45nt exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing-out the 45nt exon portion is lacking in the quaking mouse.
新潟医学会
1989-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/41300
https://niigata-u.repo.nii.ac.jp/records/22871
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
103
6
442
446
https://niigata-u.repo.nii.ac.jp/record/22871/files/103(6)_442-446.pdf
application/pdf
1.6 MB
2019-08-19