2024-03-29T12:32:31Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00022839
2022-12-15T03:53:07Z
453:456
471:537:538:1208
夫婦間リンパ球混合培養遮断抗体に対応する絨毛細胞膜抗原の解析
夫婦間リンパ球混合培養遮断抗体に対応する絨毛細胞膜抗原の解析
Studies on the Antigens Expressed on Trophoblasts Related to MLR-blocking Antibodies
後藤, 重則
trophoblast
blocking antibodies
mixed lymphocyte reaction
絨毛細胞
遮断抗体
リンパ球混合培養
The purpose of this study is to investigate the antigenic nature of trophoblasts and its relation to mixed lymphocyte reaction-blocking antibodies (MLR-BAbs). Mixed culture of lymphocytes and syncytiotrophoblasts plasma membrane (STPM) (MLSC) and absorption study of MLR-blocking effect with STPM were perfomed in the present experiments. Lymphocytes were obviously stimulated in the 9 MLSCs. And like MLR, this stimulation was specifically inhibited by corresponding mothers' sera, suggesting that lymphocytes were stimulated in MLSCs by alloantigens expressed on STPM. Nineteen sera were obtained from normal pregnant women and habitual aborters after immunotherapy. And these sera were absorbed with STPM from respective mothers' placenta (autologous STPM) and unrelated mothers' (allogeneic STPM) as a control. The HLA types of cord blood lymphocytes corresponding to these STPM were then determined. The MLR-blocking effect of every serum was removed by autologous STPM absorption, nevertheless it was removed or unaffected by allogeneic one. Comparison of paternal stimulator and cord blood lymphocytes HLA-PR types showed that some of positive absorptions with allogeneic STPM could be explained by coincidence of HLA-DR types. These findings suggested that MLR-BAbs were directed against some alloantigens expressed on trophoblasts that might be related to HLA-DR antigens.
新潟医学会
1989-07
jpn
departmental bulletin paper
http://hdl.handle.net/10191/41334
https://niigata-u.repo.nii.ac.jp/records/22839
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
103
7
549
555
https://niigata-u.repo.nii.ac.jp/record/22839/files/103(7)_549-555.pdf
application/pdf
1.5 MB
2019-08-19