2024-03-29T11:26:35Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021951
2022-12-15T03:52:24Z
453:456
471:537:538:1193
5) サイトメガロウイルス感染症(シンポジウム 各科領域におけるウイルス病学の進歩, 第449回新潟医学会)
5) サイトメガロウイルス感染症(シンポジウム 各科領域におけるウイルス病学の進歩, 第449回新潟医学会)
Cytomegalovirus Infection(Recent Progress in Medical Virology of Five Etiologies)
久保田, 康夫
cytomegalovirus
reactivation
サイトメガロウイルス
再活性化
A rural area (Suibara County) of Niigata Prefecture was investigated for the prevalence of cytomegalovirus (CMV) infection among the residents, particularly among the pregnant women and newborn infants, using serological and virological methods. Complement-fixation test revealed the incidence of CMV antibody in 93.9% of the cord-blood specimens. By employing a human diploid cell line, CMV could be isolated from urines of infants, covering the age groups of below 2-month-old to 14-year-old with a highest isolation rate of 63.3% at 9-to 11-month-old, indicating the occurrence of perinatal infection in the same rate at least. These findings in the perinatal conditions also anticipated an ubiquitous prevalence of CMV infection among the other age groups of residents and alarmed a signal for the risk of clinical hazards due to reactivation of the latent virus, provided that the individuals were subjected to a compromised state of immunity, receiving organ-transplantation for example. For the reactivation mechanisms of the latent virus in pregnancy, impairment of cellular immunity has been raised as a possibility. Pregnant women were compared with nonpregnant women for the efficiency of the peripheral lymphocytes in the blast-transformation, where the specimens of the former group gave a significatly (p<0.01) reduced rate of the reaction with CMV antigen.
新潟医学会
1990-10
jpn
departmental bulletin paper
http://hdl.handle.net/10191/34755
https://niigata-u.repo.nii.ac.jp/records/21951
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
104
10
827
834
https://niigata-u.repo.nii.ac.jp/record/21951/files/104(10)_827-834.pdf
application/pdf
1.6 MB
2019-08-16