2024-03-29T14:55:15Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021388
2022-12-15T03:51:57Z
453:456
471:537:538:1185
Serum amyloid A proteinの迅速定量法と臨床的意義に関する研究
Serum amyloid A proteinの迅速定量法と臨床的意義に関する研究
A Study on the Assay Method and Clinical Significance for Serum Amyloid A Protein
山田, 俊幸
serum amyloid A protein
C-reactive protein
inflammatory disease
血清アミロイドA蛋白
C反応性蛋白
炎症性疾患
A latex agglutination photometric immunoassay method was developed to measure serum amyloid A protein (SAA). Using an automated analyzer, the assay required 10 minutes. Standardization was possible using SAA-enriched high density lipoprotein which was obtained from a patient. The SAA content was determined electrophoretically and the result was used as the assay standard. This rapid and easy method is expected to be applied for the routine uses. Health values of SAA were somewhat higher than those of C-reactive protein (CRP). In healthy subjects and patients with acute myocardial infarction, both proteins changed in parallel. The log SAA vs log CRP ratio showed essentially the same values in patients with rheumatoid arthritis, gastrointestinal cancer, lung canncer, acute myocardial infarction, surgical operation and bacterial pneumonia, while significantly higer values were obtained in patients with rubellosis, cytomegalo virus infection and kidney allograft rejection. The serum levels of SAA and CRP may thus not always be controlled by the same mechanisms, and the measurment of SAA would be of value in certain disorders.
新潟医学会
1991-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/38898
https://niigata-u.repo.nii.ac.jp/records/21388
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
105
6
372
379
https://niigata-u.repo.nii.ac.jp/record/21388/files/105(6)_372-379.pdf
application/pdf
1.7 MB
2019-08-16