2024-03-29T00:58:40Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021289
2022-12-15T03:51:51Z
453:456
471:537:538:1183
NitroglycerinとNOによる平滑筋弛緩とそれに対するmethylene blueの作用
NitroglycerinとNOによる平滑筋弛緩とそれに対するmethylene blueの作用
Relaxation of Vascular and Nonvascular Smooth Muscles by Nitroglycerin and Nitric Oxide and the Effects Thereupon of Methylene Blue
付, 守廷
nitroglycerin
nitric oxide
methylene blue
cGMP
smooth muscle
ニトログリセリン
酸化窒素
メチレンブルー
平滑筋
Smooth muscle relaxant activity by nitroglycerin and nitric oxide was measured in the smooth muscle preparations of guinea pig aorta, trachea and taenia coli. The smooth muscle preparations were precontracted with either 100mM KCl, 30mM KCl or histamine. The relaxant potency of nitroglycerin in these smooth muscles was aorta>trachea>taenia coli. In contrast, the relaxant potency of nitric oxide was aorta>taenia coli>trachea. Methylene blue inhibited relaxation by both nitric oxide and nitroglycerin in the aorta precontracted by 100mM, 30mM K and 3×10^<-6>M histamine and in the trachea precontracted by 3×10^<-5>M histamine, but did not inhibit in the trachea precontracted by 100mM, 30mM K and in the taenia coli precontracted by 100mM, 30mM K and histamine. These results suggest that relaxation of vascular smooth muscle caused by nitric oxide and nitroglycerine is ultimately connected with the activation of soluble guanylate cyclase, but those of the trachea and taenia coli are not related with the activation of the enzyme.
新潟医学会
1991-08
jpn
departmental bulletin paper
http://hdl.handle.net/10191/39328
https://niigata-u.repo.nii.ac.jp/records/21289
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
105
8
520
527
https://niigata-u.repo.nii.ac.jp/record/21289/files/105(8)_520-527.pdf
application/pdf
1.3 MB
2019-08-16