2024-03-29T07:30:35Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021274
2022-12-15T03:51:49Z
453:456
471:537:538:1181
新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用
新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用
Pharmacological Properties of 1-[(3, 4-Dihydro-2H-(1, 3)-Thiazino[3, 2-a]Benzimidazole-2-yl)Methyl]-4-(3, 4, 5-Trimethoxycinnamoyl) Piperazine Dihydrochloride (D230), a New Coronary Vasodilating Drug
小川, 陽一郎
coronary vasodilator
adenosine
blood flow
dipyridamole
血管拡張薬
アデノシン
血流量
ジピリダモール
The cardiovascular effects of D230 were investigated in comparison with those of dipyridamole. D230 (0.3~3.0 mg/kg i.v.) produced a marked increase in coronary blood flow and a slight decrease in arterial pressure in anesthetized dogs. Concomitant with these changes decrease in total peripheral resistance without tachycardia were noted. Cardiac output and stroke volume increased with no significant changes in cardiac work and myocardial oxygen consumption. D230 potentiated the effect of adenosine. The coronary vasodilating effect of D230 was antagonised by aminophylline. These effects were almost similar to those of dipyridamole (0.1~1.0 mg/kg i.v.). In isolated taenia coli, D230 (10^<-5>~10^<-4>M) caused a partial inhibition of the spontaneous contraction as well as the K+ (30mM and 100mM)-induced contractures. Although D230 did not increase myocardial blood flow of the ischemic region, it tended to suppress the arrhythmias induced by ligation of the left anterior descending coronary artery in anesthetized dogs. D230 (10~30 mg/kg i.v.) depressed the elevation of S wave in electrocardiogram induced by methacholine in rats. These results suggest that similar to that of dipyridamole, the mechanism of the coronary vasodilation induced by D230 may be due to potentiation of action of endogenous adenosine.
新潟医学会
1991-10
jpn
departmental bulletin paper
http://hdl.handle.net/10191/39420
https://niigata-u.repo.nii.ac.jp/records/21274
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
105
10
710
724
https://niigata-u.repo.nii.ac.jp/record/21274/files/105(10)_710-724.pdf
application/pdf
3.2 MB
2019-08-16