2024-03-29T15:33:21Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00021272
2022-12-15T03:51:50Z
453:456
471:537:538:1181
中枢神経系におけるカテコラミン系に及ぼすニコチンとニコチン性アセチルコリン受容体の役割
中枢神経系におけるカテコラミン系に及ぼすニコチンとニコチン性アセチルコリン受容体の役割
Effects on Central Catecholamine System by Nicotine and Nicotinic Acetylcholine Receptor
石川, 厚
nicotine
nicotinic acetylcholine receptor
catecholamine
microdialysis
autoradiography
ニコチン
ニコチン性アセチルコリン受容体
カテコラミン
マイクロダイアリシス
オートラジオグラフィー
We observed the efficacy of cigarette smoking on familial juvenile parkinsonian patients, and considered this efficacy to nicotinic action in the CNS. We tried to confirm the nicotinic function in the rat striatum by means of in vivo microdialysis method, and examined the changes of ^3H-nicotine bindings of model rats having lesion of unilateral substantia nigra following 6OHDA injection using the method of macroautoradiography. As a result, DOPAC and HVA values following systemic nicotine injection were elevated statistically comparing to the injection of saline, and radioactivities of ^3H-nicotine of lesioned side in striatum, accumbens nucleus, olfactory tubercle were decreased statistically comparing to that of non-lesioned side. From these results nicotine and nicotinic acetylcholine receptor are supposed to be closely related to the catecholamine system in the CNS.
新潟医学会
1991-10
jpn
departmental bulletin paper
http://hdl.handle.net/10191/39416
https://niigata-u.repo.nii.ac.jp/records/21272
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
105
10
696
706
https://niigata-u.repo.nii.ac.jp/record/21272/files/105(10)_696-706.pdf
application/pdf
3.1 MB
2019-08-16