2024-03-29T08:34:55Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020939
2022-12-15T03:51:35Z
453:456
471:537:538:1173
筋緊張性ジストロフィー症患者赤血球の磁気共鳴法による研究
筋緊張性ジストロフィー症患者赤血球の磁気共鳴法による研究
Magnetic Resonance Study on the Erythrocytes from Myotonic Dystrophy
桑原, 武夫
MRS
myotonic dystrophy
erythrocyte
water permeability
Na pump
glycolysis
磁気共鳴スペクトロスコピー
筋緊張性ジストロフィー症
赤血球
水交換
ナトリウムポンプ
糖代謝
We have studied the water permeability through membranes, the function of the Na pump, and glucose metabolism of erythrocytes of patients with myotonic muscular dystrophy (MyD) using ^1H-, ^<23>Na, and ^<13>C-magnetic resonance spectroscopy (MRS). A significant decrease in water permeability was recognized in the MyD erythrocyte membrane, and impared Na pumping was suspected to be correlated with the former biochemical abnormalities in band III protein. of MyD erythrocyte membrane. Significant accelation of glycolysis in erythrocyte for the first 160 minutes was also recognized in MyD however, the production of lactate showed no difference between MyD and controls. The increased glucose uptake in MyD may be compensatory to the diminished pumping mechanism, but further information, such as inorganic phosphate permeability and the activity of the rate-limiting enzyme of erythrocyte glycolysis is needed.
新潟医学会
1992-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/39781
https://niigata-u.repo.nii.ac.jp/records/20939
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
106
6
563
572
https://niigata-u.repo.nii.ac.jp/record/20939/files/106(06)_563-572.pdf
application/pdf
1.8 MB
2019-08-16