2024-03-29T08:19:13Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020933
2022-12-15T03:51:34Z
453:456
471:537:538:1173
ラット摘出大動脈平滑筋に対する蒲公英の作用
ラット摘出大動脈平滑筋に対する蒲公英の作用
Effects of Taraxacum-Extract on the Isolated Rat Aorta
尤, 春来
仲澤, 幹雄
Taraxacum
rat aorta
vascular smooth muscle
蒲公英
ラット大動脈
血管平滑筋
Using the isolated rat aortas with or without endothelium, the effects of Taraxacum-extract on the vascular smooth muscle were studied. The contraction was induced by phenylephreine. In the preparations without endothelium Taraxacum-extract produced a dose-dependent increase in tension, while in preparations with intact endothelium high doses (0.1 and 0.3ml) of this extract produced relaxation. Taraxacum contained 265mM K^+ and 53mM Na^+. However, the solution containing 265mM K^+ and 53mM Na^+ induced only a contraction at a higher dose (0.03ml). The contraction was greater in the aorta without entodthlium than in the aorta with endothelium. Indomethacin(10^<-5> .M) had no effect on the Taraxacum-extract-induced relaxation, while the contraction induced with lower concentrations of Taraxacum-extract was potentiated. These results indicate that Taraxacum-extract produces endothelium-dependent relaxation (due probably to EDRF) at higher doses. The release of vasorelaxant prostaglandin(s) was indicated. The contraction induced with Taraxacum-extract was not due to K^+ and Na^+ ion contained in it.
新潟医学会
1992-06
jpn
departmental bulletin paper
http://hdl.handle.net/10191/39774
https://niigata-u.repo.nii.ac.jp/records/20933
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
106
6
513
517
https://niigata-u.repo.nii.ac.jp/record/20933/files/106(06)_513-517.pdf
application/pdf
900.7 kB
2019-08-16