2024-03-28T13:43:11Z
https://niigata-u.repo.nii.ac.jp/oai
oai:niigata-u.repo.nii.ac.jp:00020390
2022-12-15T03:51:05Z
453:456
471:537:538:1166
大脳半球剔除ラット残存半球皮質の蛋白代謝について : 中枢神経系の可塑性に関連して
大脳半球剔除ラット残存半球皮質の蛋白代謝について : 中枢神経系の可塑性に関連して
Protein Metabolic Change of the Remaining Cerebral Hemisphere Consequent to Hemispherectomy : In Relation to the Plasticity of Central Nervous System
渡辺, 達雄
hemisphrectomy
plasticity
protein metabolism
electrophoresis
大脳半球剔除術
可塑性
蛋白代謝
電気泳動
Remarkable functional recovery has been observed in the hemispherectomized animals and it is conceivable that the remaining cerebral hemisphere is responsible for this recovery. To disclose biochemical basis of this functinal recovery, rats were hemispherectomized neonatally or at 3 month after birth, and proteins of the remaining cerebral hemisphere were analyzed. At one, two and four weeks after the hemispherectomy, ^<14>C-labelled leucine was injected intracerebrally and rats were decapitated one hour after the injection. The proteins were fractionated into water-, Triton X100- and SDS-soluble fractions and analysed by SDS polyacrylamide gel- and by two dimensional gel-electrophoresis. CBB stained protein-profiles and relative specific activities of the main proteins calculated from densitigrams of radioautography and CBB staining were compared between the hemispherectomized rats and the control rats. The present results revealed that appreciable extent of changes in protein metabolism in the remaining cerebral hemisphere is not necessary for the functional recovery of the hemispherectomized rat.
新潟医学会
1993-01
jpn
departmental bulletin paper
http://hdl.handle.net/10191/37055
https://niigata-u.repo.nii.ac.jp/records/20390
AN00182415
00290440
新潟医学会雑誌
新潟医学会雑誌
107
1
53
64
https://niigata-u.repo.nii.ac.jp/record/20390/files/107(1)_53-64.pdf
application/pdf
3.7 MB
2019-08-16