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oai:niigata-u.repo.nii.ac.jp:00019363 2022-12-15T03:50:18Z 453:456 471:537:538:1150

1) 消化器癌の腫瘍マーカーアルファフェトプロテインを中心に(シンポジウム 腫瘍マーカーの臨床的意義, 第485回新潟医学会) 1) 消化器癌の腫瘍マーカーアルファフェトプロテインを中心に(シンポジウム 腫瘍マーカーの臨床的意義, 第485回新潟医学会) The Usefulness of the Glycosylation Indices of Human alpha-fetoprotein in the Differential Diagnosis of Neoplastic Diseases of the Liver (Clinical Usefulness of Tumor Markers) 青柳, 豊 alpha-fetoprotein hepatocellular carcinoma fucosylation index glucosaminylation index 肝細胞癌 アルファフェトプロテイン フコシル化率 グルコサミニル化率 The degrees of fucosylation (fucosylation index) and glucosaminylation (glucosaminylation index) of alpha-fetoprotein (AFP) were determined in serum samples of 437 patients with hepatocellular carcinoma (HCC), 55 with carcinoma metastatic to the liver from digestive organs and 241 with benign liver diseases. The fucosylation index of AFP in all patients with HCC (39±31%, mean±SD) was significantly higher (P<0.001) than that in patients with benign liver diseases (4±7%). When graded according to a combination of tumor size and serum AFP concentraton, 29 patients with HCC had tumor diameters less than 3 cm and serum concentrations below 400 ng/ml (group B). Twenty-five patients had tumor diameters less than 2 cm and AFP below 1,000 ng/ml (group C) and 15 had tumor diameters less than 2 cm and AFP below 400 ng/ml (group D). The mean fucosylation indices of groups B, C and D were 32±32%, 32±30% and 28±30%, respectively (Fig. 1-B, C and D). These values were higher than those in patients with benign liver diseases with statistical significance. On the other hand, the glucosaminylation index of AFP in patients with carcinoma metastatic to the liver (39±23%) was significantly higher than those in benign liver disease (4±4%) and HCC (2±6%). Thus, the combined information in these two glycosylation indices was useful for the differential diagnosis of neoplastic disases of the liver. 新潟医学会 1994-05 jpn departmental bulletin paper http://hdl.handle.net/10191/38260 https://niigata-u.repo.nii.ac.jp/records/19363 AN00182415 00290440 新潟医学会雑誌 新潟医学会雑誌 108 5 337 341 https://niigata-u.repo.nii.ac.jp/record/19363/files/108(5)_337-341.pdf application/pdf 860.0 kB 2019-08-08